4NH1
Crystal structure of a heterotetrameric CK2 holoenzyme complex carrying the Andante-mutation in CK2beta and consistent with proposed models of autoinhibition and trans-autophosphorylation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Casein kinase II subunit alpha | polymer | 335 | 40066.7 | 2 | UniProt (P68400) Pfam (PF00069) | Homo sapiens (human) | protein kinase CK2 catalytic subunit, CK2alpha, CK II alpha |
| 2 | C, D (C, D) | Casein kinase II subunit beta | polymer | 215 | 24951.4 | 2 | UniProt (P67870) Pfam (PF01214) | Homo sapiens (human) | protein kinase CK2 non-catalytic subunit, CK2beta, CK II beta, Phosvitin, Protein G5a |
| 3 | E, F, H, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G, K (A, B) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 2 | Chemie (ACP) | |||
| 5 | J (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | L, M (C, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 215 (UniProt: P67870)
| PDB | External Database | Details |
|---|---|---|
| Ile 166 | Met 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130036.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1330.5 | |
| All* | Total formula weight | 131366.8 |
