4NEU
X-ray structure of Receptor Interacting Protein 1 (RIP1)kinase domain with a 1-aminoisoquinoline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 1 | polymer | 333 | 38209.0 | 2 | UniProt (Q13546) Pfam (PF07714) | Homo sapiens (human) | Cell death protein RIP, Receptor-interacting protein 1, RIP-1, Serine/threonine-protein kinase RIP |
| 2 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | D, E (A, B) | 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea | non-polymer | 401.5 | 2 | Chemie (Q1A) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 324 (UniProt: Q13546)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76418.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 827.2 | |
| All* | Total formula weight | 77245.3 |
