4NAW

Crystal Structure of Human ATG12~ATG5-ATG16N in complex with a fragment of ATG3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M (A, E, I, M)	Ubiquitin-like protein ATG12	polymer	91	10282.0	4	UniProt (O94817) Pfam (PF04110)	Homo sapiens (human)	Autophagy-related protein 12, APG12-like
2	B, F, J, N (B, F, J, N)	Autophagy protein 5	polymer	275	32489.2	4	UniProt (Q9H1Y0) Pfam (PF20638) Pfam (PF20637) Pfam (PF04106)	Homo sapiens (human)	APG5-like, Apoptosis-specific protein
3	C, G, K, O (C, G, K, O)	Autophagy-related protein 16-1	polymer	36	4657.4	4	UniProt (Q676U5)	Homo sapiens (human)	APG16-like 1
4	D, H, L, P (D, H, L, P)	Ubiquitin-like-conjugating enzyme ATG3	polymer	34	3822.8	4	UniProt (Q9NT62)	Homo sapiens (human)	Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96
5	BA, CA, DA, Q, R... (N, B, F, J)	SULFATE ION	non-polymer		96.1	11	Chemie (SO4)
6	AA, EA, S, V (J, N, B, F)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
7	FA, GA, HA, IA, JA... (A, B, C, E, F...)	water	water		18.0	597	Chemie (HOH)

Sequence modifications

A, E, I, M: 52 - 140 (UniProt: O94817)

PDB	External Database	Details
Gly 50	-	expression tag
Ser 51	-	expression tag

C, G, K, O: 11 - 43 (UniProt: Q676U5)

PDB	External Database	Details
Ser 8	-	expression tag
His 9	-	expression tag
Met 10	-	expression tag

D, H, L, P: 140 - 170 (UniProt: Q9NT62)

PDB	External Database	Details
Gly 137	-	expression tag
His 138	-	expression tag
Met 139	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	205005.9
Non-Polymers*	Number of molecules	15
	Total formula weight	1148.7
All*	Total formula weight	206154.6

*Water molecules are not included.