4NAW

Crystal Structure of Human ATG12~ATG5-ATG16N in complex with a fragment of ATG3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M	Ubiquitin-like protein ATG12	polymer	91	10282.0	4	UniProt (O94817) Pfam (PF04110) In PDB	Homo sapiens (human)	Autophagy-related protein 12, APG12-like
2	B, F, J, N	Autophagy protein 5	polymer	275	32489.2	4	UniProt (Q9H1Y0) Pfam (PF20638) Pfam (PF20637) Pfam (PF04106) In PDB	Homo sapiens (human)	APG5-like, Apoptosis-specific protein
3	C, G, K, O	Autophagy-related protein 16-1	polymer	36	4657.4	4	UniProt (Q676U5) In PDB	Homo sapiens (human)	APG16-like 1
4	D, H, L, P	Ubiquitin-like-conjugating enzyme ATG3	polymer	34	3822.8	4	UniProt (Q9NT62) In PDB	Homo sapiens (human)	Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96
5	N, B, F, J	SULFATE ION	non-polymer		96.1	11	Chemie (SO4)
6	J, N, B, F	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
7		water	water		18.0	597	Chemie (HOH)

Sequence modifications

A, E, I, M: 52 - 140 (UniProt: O94817)

PDB	External Database	Details
Gly 50	-	EXPRESSION TAG
Ser 51	-	EXPRESSION TAG

C, G, K, O: 11 - 43 (UniProt: Q676U5)

PDB	External Database	Details
Ser 8	-	EXPRESSION TAG
His 9	-	EXPRESSION TAG
Met 10	-	EXPRESSION TAG

D, H, L, P: 140 - 170 (UniProt: Q9NT62)

PDB	External Database	Details
Gly 137	-	EXPRESSION TAG
His 138	-	EXPRESSION TAG
Met 139	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	205005.9
Non-Polymers*	Number of molecules	15
	Total formula weight	1148.7
All*	Total formula weight	206154.6

*Water molecules are not included.