4N9C
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nicotinamide phosphoribosyltransferase | polymer | 501 | 56942.4 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB | Homo sapiens (human) | NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin |
2 | A, B | 5-nitro-1H-benzimidazole | non-polymer | 163.1 | 2 | Chemie (2ZM) | |||
3 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
4 | water | water | 18.0 | 1133 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
PDB | External Database | Details |
---|---|---|
Leu 492 | - | expression tag |
Glu 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
His 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
His 500 | - | expression tag |
His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 113884.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 516.2 | |
All* | Total formula weight | 114401.0 |