4N6P

Crystal Structure of C-lobe of Bovine lactoferrin complexed with meclofenamic acid at 1.4 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Lactotransferrin	polymer	341	37257.1	1	UniProt (P24627) Pfam (PF00405) In PDB	Bos taurus (bovine cow domestic cattle domestic cow)	Lactoferrin, Lactoferricin-B, Lfcin-B
2	B	C-terminal peptide from Lactotransferrin	polymer	6	652.8	1	UniProt (P24627) In PDB	Bos taurus (bovine cow domestic cattle domestic cow)	Lactoferrin, Lactoferricin-B, Lfcin-B
3	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	A	FE (III) ION	non-polymer		55.8	1	Chemie (FE)
6	A	CARBONATE ION	non-polymer		60.0	1	Chemie (CO3)
7	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
8	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
10	A	2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid	non-polymer		296.1	1	Chemie (JMS)
11		water	water		18.0	305	Chemie (HOH)

Sequence modifications

A: 342 - 676 (UniProt: P24627)

PDB	External Database	Details
Lys 565	Asn 584	engineered mutation
Glu 608	Lys 627	engineered mutation
Leu 677	-	expression tag
Glu 678	-	expression tag
Ala 679	-	expression tag
Cys 680	-	expression tag
Ala 681	-	expression tag
Phe 682	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37909.8
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	8
	Total formula weight	978.9
All*	Total formula weight	39737.5

*Water molecules are not included.