4N4S
A Double Mutant Rat Erk2 in Complex With a Pyrazolo[3,4-d]pyrimidine Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase 1 | polymer | 359 | 41353.5 | 2 | UniProt (P63086) Pfam (PF00069) | Rattus norvegicus (rat) | MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 |
| 2 | C, D (A, B) | 3-[2-(benzyloxy)-8-methylquinolin-6-yl]-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 424.5 | 2 | Chemie (2H1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 358 (UniProt: P63086)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Asn 1 | - | expression tag |
| Ala 103 | Gln 103 | engineered mutation |
| Leu 164 | Cys 164 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82707.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 849.0 | |
| All* | Total formula weight | 83556.0 |
