4N3Z

Crystal structure of Rabex-5delta and Rabaptin-5C21 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Rab5 GDP/GTP exchange factor	polymer	310	36564.0	1	UniProt (Q9UJ41) Pfam (PF18151) Pfam (PF02204) In PDB	Homo sapiens (human)	Rabex-5delta, RAP1, Rabaptin-5-associated exchange factor for Rab5, Rabex-5
2	B, C	Rab GTPase-binding effector protein 1	polymer	92	10701.1	2	UniProt (Q15276) In PDB	Homo sapiens (human)	Rabaptin-5C21, Rabaptin-4, Rabaptin-5, Rabaptin-5alpha, Renal carcinoma antigen NY-REN-17
3	A, B, C	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)

Sequence modifications

A: 132 - 433 (UniProt: Q9UJ41)

PDB	External Database	Details
Met 124	-	expression tag
Gly 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
-	Gly 387	deletion
-	Gln 388	deletion
-	Thr 389	deletion
-	Ser 390	deletion
-	Pro 391	deletion
-	Arg 392	deletion
-	Lys 393	deletion
-	Gln 394	deletion
-	Glu 395	deletion
-	Ala 396	deletion
-	Glu 397	deletion
-	Ser 398	deletion
-	Trp 399	deletion
-	Ser 400	deletion
-	Pro 401	deletion
-	Asp 402	deletion
-	Ala 403	deletion
-	Cys 404	deletion
-	Leu 405	deletion
-	Gly 406	deletion
-	Val 407	deletion
-	Lys 408	deletion

B, C: 552 - 642 (UniProt: Q15276)

PDB	External Database	Details
Met 551	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	57966.2
Non-Polymers*	Number of molecules	3
	Total formula weight	284.9
All*	Total formula weight	58251.1

*Water molecules are not included.