4N1T
Structure of human MTH1 in complex with TH287
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 159 | 18253.7 | 1 | UniProt (P36639) Pfam (PF00293) In PDB | Homo sapiens (human) | 2-hydroxy-dATP diphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1 |
| 2 | A | 6-(2,3-dichlorophenyl)-N~4~-methylpyrimidine-2,4-diamine | non-polymer | 269.1 | 1 | Chemie (2GD) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A: 1 - 156 (UniProt: P36639)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18253.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 653.4 | |
| All* | Total formula weight | 18907.1 |
