4N1K
Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NACHT, LRR and PYD domains-containing protein 14 | polymer | 105 | 12249.0 | 4 | UniProt (Q86W24) Pfam (PF02758) | Homo sapiens (human) | Nucleotide-binding oligomerization domain protein 5 |
| 2 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 100 (UniProt: Q86W24)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Val 86 | Asp 86 | engineered mutation |
| Leu 101 | - | expression tag |
| Glu 102 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 48996.2 | |
| All* | Total formula weight | 48996.2 |
