4N0U
Ternary complex between Neonatal Fc receptor, serum albumin and Fc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | IgG receptor FcRn large subunit p51 | polymer | 264 | 29433.1 | 1 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor |
| 2 | B (B) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 3 | C (D) | Serum albumin | polymer | 583 | 66385.1 | 1 | UniProt (P02768) Pfam (PF00273) | Homo sapiens (human) | |
| 4 | D (E) | Ig gamma-1 chain C region | polymer | 209 | 23765.7 | 1 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | |
| 5 | E (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 1 | In PDB GlyTouCan (G59451NL) |
Sequence modifications
E: 236 - 444 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Tyr 252 | Met 135 | engineered mutation |
| Thr 254 | Ser 137 | engineered mutation |
| Glu 256 | Thr 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 131332.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1463.3 | |
| All* | Total formula weight | 132795.4 |
