4MXZ
Src M314L T338M double mutant bound to kinase inhibitor bosutinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32722.6 | 2 | UniProt (P12931) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-Src, pp60c-src, p60-Src |
| 2 | C, D (A, B) | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | non-polymer | 530.4 | 2 | Chemie (DB8) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P12931)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
| Leu 314 | Met 317 | engineered mutation |
| Met 338 | Thr 341 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65445.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1060.9 | |
| All* | Total formula weight | 66506.2 |
