4MWF

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core bound to broadly neutralizing antibody AR3C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, H)	Fab AR3C heavy chain	polymer	233	24627.5	2		Homo sapiens (human)
2	B, F (B, L)	Fab AR3C light chain	polymer	214	23266.8	2		Homo sapiens (human)
3	C, D (C, D)	Envelope glycoprotein E2	polymer	212	23286.4	2	UniProt (P27958) Pfam (PF01560)	Hepatitis C virus (isolate H) (HCV)
4	G (E)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1397.2	1	In PDB GlyTouCan (G81980VO)
5	H, I (F, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	J, K, L, M, N... (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)

Sequence modifications

C, D: 412 - 459 (UniProt: P27958)

PDB	External Database	Details
Asp 448	Asn 448	engineered mutation

C, D: 486 - 645 (UniProt: P27958)

PDB	External Database	Details
Gly 482	-	linker
Ser 483	-	linker
Ser 484	-	linker
Gly 485	-	linker
Asp 576	Asn 576	engineered mutation
His 589	Tyr 589	variant
Trp 602	Arg 602	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	142361.4
Branched	Number of molecules	3
	Total formula weight	2246.0
Non-Polymers*	Number of molecules	7
	Total formula weight	1548.5
All*	Total formula weight	146155.9

*Water molecules are not included.