4MWF
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core bound to broadly neutralizing antibody AR3C
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, H | Fab AR3C heavy chain | polymer | 233 | 24627.5 | 2 | Homo sapiens (human) | ||
2 | B, L | Fab AR3C light chain | polymer | 214 | 23266.8 | 2 | Homo sapiens (human) | ||
3 | C, D | Envelope glycoprotein E2 | polymer | 212 | 23286.4 | 2 | UniProt (P27958) Pfam (PF01560) In PDB | Hepatitis C virus (isolate H) (HCV) | |
4 | E | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G81980VO) | |||
5 | F, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
6 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) |
Sequence modifications
C, D: 412 - 459 (UniProt: P27958)
C, D: 486 - 645 (UniProt: P27958)
PDB | External Database | Details |
---|---|---|
Asp 448 | Asn 448 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 482 | - | linker |
Ser 483 | - | linker |
Ser 484 | - | linker |
Gly 485 | - | linker |
Asp 576 | Asn 576 | engineered mutation |
His 589 | Tyr 589 | variant |
Trp 602 | Arg 602 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 142361.4 | |
Branched | Number of molecules | 3 |
Total formula weight | 2246.0 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1548.5 | |
All* | Total formula weight | 146155.9 |