4MPU
Human beta-tryptase co-crystal structure with (6S,8R)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-8-hydroxy-6-(1-hydroxycyclobutyl)-5,7-dioxaspiro[3.4]octane-6,8-dicarboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tryptase alpha/beta-1 | polymer | 245 | 27491.4 | 2 | UniProt (Q15661) Pfam (PF00089) In PDB | Homo sapiens (human) | Tryptase-1, Tryptase I, Tryptase alpha-1 |
| 2 | A, B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | A, B | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 5 | B | (6S,8R)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-8-hydroxy-6-(1-hydroxycyclobutyl)-5,7-dioxaspiro[3.4]octane-6,8-dicarboxamide | non-polymer | 871.0 | 1 | Chemie (X2A) | |||
| 6 | water | water | 18.0 | 515 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 275 (UniProt: Q15661)
| PDB | External Database | Details |
|---|---|---|
| Lys 132 | Asn 132 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54982.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2034.2 | |
| All* | Total formula weight | 57017.1 |
