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4MP7

Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA7

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrialpolymer40045233.41UniProt (Q15119)
Pfam (PF10436)
Pfam (PF02518)
Homo sapiens (human)Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII
2B
(A)
4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diolnon-polymer255.31Chemie (PFT)
3C
(A)
L(+)-TARTARIC ACIDnon-polymer150.11Chemie (TLA)
4D
(A)
waterwater18.0213Chemie (HOH)
Sequence modifications
A: 9 - 407 (UniProt: Q15119)
PDBExternal DatabaseDetails
Ser 8-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight45233.4
Non-Polymers*Number of molecules2
Total formula weight405.4
All*Total formula weight45638.8
*Water molecules are not included.

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PDB entries from 2025-08-13

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