4MMV

Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1-TriC at pH 9.5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fusion glycoprotein F2	polymer	82	9215.4	1	UniProt (P03420) In PDB	Human respiratory syncytial virus A2
2	B	Fusion glycoprotein F1 fused with Fibritin trimerization domain	polymer	414	45693.3	1	UniProt (P03420) UniProt (P10104) Pfam (PF00523) In PDB	Human respiratory syncytial virus A2
3		water	water		18.0	73	Chemie (HOH)

Sequence modifications

A: 26 - 107 (UniProt: P03420)

PDB	External Database	Details
Ala 102	Pro 102	engineered mutation

B: 137 - 513 (UniProt: P03420)

PDB	External Database	Details
Cys 155	Ser 155	engineered mutation
Phe 190	Ser 190	engineered mutation
Leu 207	Val 207	engineered mutation
Cys 290	Ser 290	engineered mutation
Val 379	Ile 379	engineered mutation
Val 447	Met 447	engineered mutation
His 486	Asp 486	engineered mutation
Gln 487	Glu 487	engineered mutation
Trp 488	Phe 488	engineered mutation
His 489	Asp 489	engineered mutation
Ser 514	-	linker
Ala 515	-	linker
Ile 516	-	linker
Gly 517	-	linker

B: 518 - 544 (UniProt: P10104)

PDB	External Database	Details
Leu 539	Phe 479	variant
Gly 545	-	expression tag
Gly 546	-	expression tag
Leu 547	-	expression tag
Val 548	-	expression tag
Pro 549	-	expression tag
Arg 550	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54908.7
All*	Total formula weight	54908.7

*Water molecules are not included.