4MMC
Crystal structure of LeuBAT (delta6 mutant) in complex with desvenlafaxine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transporter | polymer | 519 | 58068.4 | 1 | UniProt (O67854) Pfam (PF00209) | Aquifex aeolicus | |
| 2 | B, C (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 3 | D, E (A) | 4-[(1R)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol | non-polymer | 263.4 | 2 | Chemie (29J) | |||
| 4 | F, G (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 2 | Chemie (BOG) | |||
| 5 | H (A) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 1 - 513 (UniProt: O67854)
| PDB | External Database | Details |
|---|---|---|
| Tyr 21 | Asn 21 | engineered mutation |
| Asp 24 | Gly 24 | engineered mutation |
| Ser 254 | Thr 254 | engineered mutation |
| Gly 256 | Ser 256 | engineered mutation |
| Phe 265 | Tyr 265 | engineered mutation |
| Gly 359 | Ile 359 | engineered mutation |
| Gly 514 | - | expression tag |
| Thr 515 | - | expression tag |
| Leu 516 | - | expression tag |
| Val 517 | - | expression tag |
| Pro 518 | - | expression tag |
| Arg 519 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 58068.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1157.5 | |
| All* | Total formula weight | 59225.9 |
