4MJU
Influenza Neuraminidase in complex with a novel antiviral compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neuraminidase | polymer | 389 | 43065.4 | 1 | UniProt (Q07599) Pfam (PF00064) | Influenza A virus | |
| 2 | B (A) | (5R,9R,10S)-10-(acetylamino)-2-amino-4-oxo-9-(pentan-3-yloxy)-1-thia-3-azaspiro[4.5]deca-2,6-diene-7-carboxylic acid | non-polymer | 369.4 | 1 | Chemie (27S) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (A) | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A: 83 - 470 (UniProt: Q07599)
| PDB | External Database | Details |
|---|---|---|
| Val 94 | Ala 92 | conflict |
| Ile 215 | Val 214 | conflict |
| Ala 266 | Thr 265 | conflict |
| Asn 294 | Gly 293 | conflict |
| Ala 330 | Thr 329 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43065.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 409.5 | |
| All* | Total formula weight | 43474.9 |
