4MIB
Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with Compound 48 (N-({(3S)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-DIRECTED RNA POLYMERASE | polymer | 570 | 63354.7 | 2 | UniProt (P26663) Pfam (PF00998) | Hepatitis C virus (HCV) | NS5B, p68 |
| 2 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | D, E (A, B) | N-({(3S)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide | non-polymer | 484.6 | 2 | Chemie (28M) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 492 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 570 (UniProt: P26663)
| PDB | External Database | Details |
|---|---|---|
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 126709.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1047.4 | |
| All* | Total formula weight | 127756.8 |
