4MGK
Selective activation of Epac1 and Epac2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Rap guanine nucleotide exchange factor 4 | polymer | 694 | 79276.8 | 1 | UniProt (Q9EQZ6) Pfam (PF00027) Pfam (PF00618) Pfam (PF00617) | Mus musculus (mouse) | Exchange factor directly activated by cAMP 2, Exchange protein directly activated by cAMP 2, EPAC 2, cAMP-dependent Rap1 guanine-nucleotide exchange factor, cAMP-regulated guanine nucleotide exchange factor II, cAMP-GEFII |
| 2 | B (R) | Ras-related protein Rap-1b | polymer | 167 | 19020.5 | 1 | UniProt (P61224) Pfam (PF00071) | Homo sapiens (human) | GTP-binding protein smg p21B |
| 3 | C (E) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 1 | Chemie (CMP) PubChem (6076) PubChem (176488666) PubChem (216878) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (25322946) PubChem (3080770) PubChem (56973690) PubChem (3246347) PubChem (59909322) PubChem (59968988) PubChem (59350541) PubChem (70878457) PubChem (274) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (12071879) PubChem (12866365) PubChem (6604194) PubChem (124132380) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (163043517) PubChem (138107790) PubChem (163043518) | |||
| 4 | D (R) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F (E, R) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
E: 306 - 993 (UniProt: Q9EQZ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 300 | - | expression tag |
| Ser 301 | - | expression tag |
| Pro 302 | - | expression tag |
| Glu 303 | - | expression tag |
| Ser 304 | - | expression tag |
| Phe 305 | - | expression tag |
| Gln 405 | Lys 423 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98297.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 425.3 | |
| All* | Total formula weight | 98722.6 |
