4MGD
Crystal structure of hERa-LBD (Y537S) in complex with HPTE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 255 | 29054.2 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (B) | Estrogen receptor | polymer | 255 | 29070.2 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (F, G) | Nuclear receptor coactivator 1 | polymer | 13 | 1591.9 | 2 | UniProt (Q15788) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 4 | E, F (A, B) | 4,4'-(2,2,2-trichloroethane-1,1-diyl)diphenol | non-polymer | 317.6 | 2 | Chemie (27N) | |||
| 5 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | I, J, K, L (A, B, F, G) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A: 302 - 552 (UniProt: P03372)
B: 302 - 552 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 298 | - | expression tag |
| Ser 299 | - | expression tag |
| His 300 | - | expression tag |
| Met 301 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 298 | - | expression tag |
| Ser 299 | - | expression tag |
| His 300 | - | expression tag |
| Met 301 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61308.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 789.4 | |
| All* | Total formula weight | 62097.5 |
