4MG8
Crystal structure of hERa-LBD (Y537S) in complex with alpha-zearalanol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 255 | 29070.2 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (B) | Estrogen receptor | polymer | 255 | 29086.2 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (C, D) | Nuclear receptor coactivator 1 | polymer | 13 | 1591.9 | 2 | UniProt (Q15788) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 4 | E, H (A, B) | alpha-zearalanol | non-polymer | 322.4 | 2 | Chemie (27J) | |||
| 5 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | G, I, J (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 7 | K, L, M (A, B, C) | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A: 302 - 552 (UniProt: P03372)
B: 302 - 552 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 298 | - | expression tag |
| Ser 299 | - | expression tag |
| His 300 | - | expression tag |
| Met 301 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 298 | - | expression tag |
| Ser 299 | - | expression tag |
| His 300 | - | expression tag |
| Met 301 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61340.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 923.1 | |
| All* | Total formula weight | 62263.3 |
