4MF3
Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Glutamate receptor ionotropic, kainate 1 | polymer | 261 | 29609.0 | 2 | UniProt (P39086) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (human) | GluK1, Excitatory amino acid receptor 3, EAA3, Glutamate receptor 5, GluR-5, GluR5 |
| 2 | A, B | (3S,4aS,6S,8aR)-6-[3-chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydroisoquinoline-3-carboxylic acid | non-polymer | 377.8 | 2 | Chemie (SXI) | |||
| 3 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B: 120 - 260 (UniProt: P39086)
A, B: 1 - 119 (UniProt: P39086)
A, B: 1 - 119 (UniProt: P39086)
| PDB | External Database | Details |
|---|---|---|
| Gly 261 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59217.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 755.6 | |
| All* | Total formula weight | 59973.6 |
