4MF3

Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glutamate receptor ionotropic, kainate 1	polymer	261	29609.0	2	UniProt (P39086) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (human)	GluK1, Excitatory amino acid receptor 3, EAA3, Glutamate receptor 5, GluR-5, GluR5
2	C, D (A, B)	(3S,4aS,6S,8aR)-6-[3-chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydroisoquinoline-3-carboxylic acid	non-polymer		377.8	2	Chemie (SXI)
3	E, F (A, B)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

A, B: 120 - 260 (UniProt: P39086)
A, B: 1 - 119 (UniProt: P39086)

PDB	External Database	Details
Gly 261	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59217.9
Non-Polymers*	Number of molecules	2
	Total formula weight	755.6
All*	Total formula weight	59973.6

*Water molecules are not included.