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4MEN

Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ABromodomain-containing protein 4polymer12715099.41UniProt (O60885)
Pfam (PF00439)
In PDB
Homo sapiens (human)Protein HUNK1
2A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
3AN,5-dimethyl-N-(4-methylbenzyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-aminenon-polymer267.31Chemie (25K)
4waterwater18.0192Chemie (HOH)
Sequence modifications
A: 44 - 168 (UniProt: O60885)
PDBExternal DatabaseDetails
Ser 42-expression tag
Met 43-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight15099.4
Non-Polymers*Number of molecules2
Total formula weight329.4
All*Total formula weight15428.8
*Water molecules are not included.

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PDB entries from 2024-07-17

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