4MBI
Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein kinase pim-1 | polymer | 293 | 33846.3 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (human) | |
2 | A | N,N-dimethyl-N'-[3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]ethane-1,2-diamine | non-polymer | 271.3 | 1 | Chemie (26K) | |||
3 | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A: 29 - 313 (UniProt: P11309)
PDB | External Database | Details |
---|---|---|
Val 314 | - | expression tag |
Glu 315 | - | expression tag |
His 316 | - | expression tag |
His 317 | - | expression tag |
His 318 | - | expression tag |
His 319 | - | expression tag |
His 320 | - | expression tag |
His 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33846.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 271.3 | |
All* | Total formula weight | 34117.7 |