4M6W

Crystal structure of the C-terminal segment of FANCM in complex with FAAP24

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fanconi anemia group M protein	polymer	221	25132.9	1	UniProt (Q8IYD8) Pfam (PF02732)	Homo sapiens (human)	Protein FACM, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog
2	B (B)	Fanconi anemia-associated protein of 24 kDa	polymer	208	23397.3	1	UniProt (Q9BTP7) Pfam (PF17949) Pfam (PF12826)	Homo sapiens (human)
3	C, D, E (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	F, G (A, B)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A: 1813 - 2031 (UniProt: Q8IYD8)

PDB	External Database	Details
Met 1811	-	expression tag
Gly 1812	-	expression tag

B: 17 - 215 (UniProt: Q9BTP7)

PDB	External Database	Details
Met 16	-	expression tag
Leu 216	-	expression tag
Glu 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48530.1
Non-Polymers*	Number of molecules	3
	Total formula weight	288.2
All*	Total formula weight	48818.3

*Water molecules are not included.