4LZR
Crystal Structure of BRD4(1) bound to Colchicine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 127 | 15043.2 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 2 | B (A) | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide | non-polymer | 399.4 | 1 | Chemie (LOC) | |||
| 3 | C (A) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ala 42 | - | expression tag |
| Met 43 | - | expression tag |
| Glu 64 | Gln 64 | conflict |
| Asp 116 | Asn 116 | conflict |
| Ser 155 | Lys 155 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15043.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 399.4 | |
| All* | Total formula weight | 15442.7 |
