4LZO

Crystal structure of human PRS1 A87T mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ribose-phosphate pyrophosphokinase 1	polymer	326	35980.4	2	UniProt (P60891) Pfam (PF13793) Pfam (PF14572)	Homo sapiens (human)	PPRibP, Phosphoribosyl pyrophosphate synthase I, PRS-I
2	C, D, E, F, G... (A, B)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)

Sequence modifications

A, B: 1 - 318 (UniProt: P60891)

PDB	External Database	Details
Thr 87	Ala 87	engineered mutation
Leu 319	-	expression tag
Glu 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71960.8
Non-Polymers*	Number of molecules	6
	Total formula weight	576.4
All*	Total formula weight	72537.2

*Water molecules are not included.