4LZN

Crystal structure of human PRS1 D65N mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Ribose-phosphate pyrophosphokinase 1	polymer	326	35949.4	2	UniProt (P60891) Pfam (PF13793) Pfam (PF14572)	Homo sapiens (human)	PPRibP, Phosphoribosyl pyrophosphate synthase I, PRS-I
2	C, D, E, F, G... (B, A)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
3	I, J (B, A)	water	water		18.0	69	Chemie (HOH)

Sequence modifications

B, A: 1 - 318 (UniProt: P60891)

PDB	External Database	Details
Asn 65	Asp 65	engineered mutation
Leu 319	-	expression tag
Glu 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71898.8
Non-Polymers*	Number of molecules	6
	Total formula weight	576.4
All*	Total formula weight	72475.2

*Water molecules are not included.