4LZ4

X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 3 nucleobase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Thrombin light chain	polymer	36	4096.5	2	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (human)	Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain
2	B, D	Thrombin heavy chain	polymer	259	29780.2	2	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (human)	Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin heavy chain
3	E, F	Thrombin Binding Aptamer (TBA)	polymer	15	4619.0	2
4	B, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	B, D	D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide	non-polymer		454.0	2	BIRD (PRD_000020) Chemie (0G6)
6	B, D	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
7	E, F	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
8		water	water		18.0	219	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	76991.4
Non-Polymers*	Number of molecules	8
	Total formula weight	1474.6
All*	Total formula weight	78466.0

*Water molecules are not included.