4LYG

Crystal structure of human PRS1 E43T mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ribose-phosphate pyrophosphokinase 1	polymer	326	35922.4	2	UniProt (P60891) Pfam (PF13793) Pfam (PF14572) In PDB	Homo sapiens (human)	PPRibP, Phosphoribosyl pyrophosphate synthase I, PRS-I
2	A, B	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)

Sequence modifications

A, B: 1 - 318 (UniProt: P60891)

PDB	External Database	Details
Thr 43	Glu 43	engineered mutation
Leu 319	-	expression tag
Glu 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71844.7
Non-Polymers*	Number of molecules	5
	Total formula weight	480.3
All*	Total formula weight	72325.0

*Water molecules are not included.