4LVD
Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Nicotinamide phosphoribosyltransferase | polymer | 501 | 56942.4 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB | Homo sapiens (human) | NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin |
2 | B, A | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
3 | B, A | N-(4-nitrophenyl)cyclopropanecarboxamide | non-polymer | 206.2 | 2 | Chemie (1EB) | |||
4 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
5 | water | water | 18.0 | 989 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 491 (UniProt: P43490)
PDB | External Database | Details |
---|---|---|
Leu 492 | - | expression tag |
Glu 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
His 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
His 500 | - | expression tag |
His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 113884.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 854.3 | |
All* | Total formula weight | 114739.1 |