4LNB

Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	CaaX farnesyltransferase alpha subunit Ram2	polymer	367	42391.5	1	UniProt (Q4WP27) Pfam (PF01239)	Aspergillus fumigatus
2	B (B)	CaaX farnesyltransferase beta subunit Ram1	polymer	519	56635.8	1	UniProt (Q4WPS9) Pfam (PF00432)	Aspergillus fumigatus
3	C, D, E, I, J (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
4	F (B)	FARNESYL DIPHOSPHATE	non-polymer		382.3	1	Chemie (FPP)
5	G (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6	H (B)	tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(2-methylphenyl)sulfonyl]amino}methyl)piperidine-1-carboxylate	non-polymer		606.8	1	Chemie (ED5)
7	K, L (A, B)	water	water		18.0	533	Chemie (HOH)

Sequence modifications

A: 1 - 353 (UniProt: Q4WP27)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Ser 146	Asn 146	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	99027.3
Non-Polymers*	Number of molecules	8
	Total formula weight	1364.9
All*	Total formula weight	100392.1

*Water molecules are not included.