4LLX

Crystal structure of PDE10A2 with fragment ZT434

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	polymer	345	39479.2	2	UniProt (Q9Y233)	Homo sapiens (human)
2	C (A)	4,6-dimethylpyrimidin-2-amine	non-polymer		123.2	1	Chemie (5ZE)
3	D, E, F, G (A, B)	NICKEL (II) ION	non-polymer		58.7	4	Chemie (NI)
4	H, I (A, B)	water	water		18.0	358	Chemie (HOH)

Sequence modifications

A, B: 449 - 789 (UniProt: Q9Y233)

PDB	External Database	Details
Gly 445	-	expression tag
Ala 446	-	expression tag
Gly 447	-	expression tag
Thr 448	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78958.5
Non-Polymers*	Number of molecules	5
	Total formula weight	357.9
All*	Total formula weight	79316.4

*Water molecules are not included.