4LIQ
Structure of the extracellular domain of human CSF-1 receptor in complex with the Fab fragment of RG7155
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Macrophage colony-stimulating factor 1 receptor | polymer | 553 | 61172.7 | 1 | UniProt (P07333) Pfam (PF00047) Pfam (PF13927) | Homo sapiens (human) | CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms |
| 2 | B (H) | Fab fragment RG7155 heavy chain | polymer | 223 | 23845.7 | 1 | Mus musculus (mouse) | ||
| 3 | C (L) | Fab fragment RG7155 light chain | polymer | 213 | 23381.8 | 1 | Mus musculus (mouse) | ||
| 4 | D (A) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | E (B) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | F (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | G (L) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 8 | H, I, J (E, H, L) | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence modifications
E: 2 - 512 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ala 513 | - | expression tag |
| Ala 514 | - | expression tag |
| Ala 515 | - | expression tag |
| Leu 516 | - | expression tag |
| Glu 517 | - | expression tag |
| Val 518 | - | expression tag |
| Leu 519 | - | expression tag |
| Phe 520 | - | expression tag |
| Gln 521 | - | expression tag |
| Gly 522 | - | expression tag |
| Pro 523 | - | expression tag |
| Gly 524 | - | expression tag |
| Thr 525 | - | expression tag |
| His 526 | - | expression tag |
| His 527 | - | expression tag |
| His 528 | - | expression tag |
| His 529 | - | expression tag |
| His 530 | - | expression tag |
| His 531 | - | expression tag |
| His 532 | - | expression tag |
| His 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| Ile 536 | - | expression tag |
| Gly 537 | - | expression tag |
| Leu 538 | - | expression tag |
| Asn 539 | - | expression tag |
| Asp 540 | - | expression tag |
| Ile 541 | - | expression tag |
| Phe 542 | - | expression tag |
| Glu 543 | - | expression tag |
| Ala 544 | - | expression tag |
| Gln 545 | - | expression tag |
| Lys 546 | - | expression tag |
| Ile 547 | - | expression tag |
| Glu 548 | - | expression tag |
| Trp 549 | - | expression tag |
| His 550 | - | expression tag |
| Glu 551 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 108400.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1100.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 317.3 | |
| All* | Total formula weight | 109817.6 |
