4LH5
Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Integrase | polymer | 182 | 20139.6 | 1 | UniProt (Q9WJM2) Pfam (PF00665) UniProt (by SIFTS) (P12497) In PDB | Human immunodeficiency virus 1 | |
2 | A | (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid | non-polymer | 405.5 | 1 | Chemie (LF0) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: Q9WJM2)
PDB | External Database | Details |
---|---|---|
Met 31 | - | expression tag |
Gly 32 | - | expression tag |
Ser 33 | - | expression tag |
Ser 34 | - | expression tag |
His 35 | - | expression tag |
His 36 | - | expression tag |
His 37 | - | expression tag |
His 38 | - | expression tag |
His 39 | - | expression tag |
His 40 | - | expression tag |
Ser 41 | - | expression tag |
Ser 42 | - | expression tag |
Gly 43 | - | expression tag |
Leu 44 | - | expression tag |
Val 45 | - | expression tag |
Pro 46 | - | expression tag |
Arg 47 | - | expression tag |
Gly 48 | - | expression tag |
Ser 49 | - | expression tag |
Val 113 | Ile 113 | variant |
Lys 185 | Phe 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 20139.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 429.8 | |
All* | Total formula weight | 20569.4 |