4LH3

Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with glutarate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	polymer	563	61954.2	2	UniProt (Q8CHT0) Pfam (PF00171)	Mus musculus (mouse)	P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1
2	C, E (A, B)	PENTAETHYLENE GLYCOL	non-polymer		238.3	2	Chemie (1PE)
3	D, F (A, B)	GLUTARIC ACID	non-polymer		132.1	2	Chemie (GUA)
4	G, H (A, B)	water	water		18.0	711	Chemie (HOH)

Sequence modifications

A, B: 22 - 563 (UniProt: Q8CHT0)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Leu 14	-	expression tag
Val 15	-	expression tag
Pro 16	-	expression tag
Arg 17	-	expression tag
Gly 18	-	expression tag
Ser 19	-	expression tag
His 20	-	expression tag
Met 21	-	expression tag
Ala 33	Thr 32	conflict
Thr 61	Met 60	conflict
Lys 468	Gln 467	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	123908.4
Non-Polymers*	Number of molecules	4
	Total formula weight	740.8
All*	Total formula weight	124649.2

*Water molecules are not included.