4LGH
Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 277 | 31757.6 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (bantam chickens) | Proto-oncogene c-Src, pp60c-src, p60-Src |
| 2 | C, D (A, B) | 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 331.4 | 2 | Chemie (0JN) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A, B: 257 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 338 | Thr 338 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63515.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 662.8 | |
| All* | Total formula weight | 64177.9 |
