4LE9

Crystal structure of a chimeric c-Src-SH3 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Proto-oncogene tyrosine-protein kinase Src	polymer	78	8677.6	1	UniProt (P00523) Pfam (PF00018)	Gallus gallus (bantam chickens)	Proto-oncogene c-Src, pp60c-src, p60-Src
2	B (A)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
3	C (A)	water	water		18.0	62	Chemie (HOH)

Sequence modifications

A: 85 - 141 (UniProt: P00523)

PDB	External Database	Details
Met 64	-	initiating methionine
Gly 65	-	expression tag
Ser 66	-	expression tag
Ser 67	-	expression tag
His 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
Ser 74	-	expression tag
Ser 75	-	expression tag
Gly 76	-	expression tag
Leu 77	-	expression tag
Val 78	-	expression tag
Pro 79	-	expression tag
Arg 80	-	expression tag
Gly 81	-	expression tag
Ser 82	-	expression tag
His 83	-	expression tag
Met 84	-	expression tag
Val 93	Glu 93	engineered mutation
Ala 94	Ser 94	engineered mutation
Ser 95	Arg 95	engineered mutation
Gly 96	Thr 96	engineered mutation
Gly 112	Asn 112	engineered mutation
Tyr 113	Asn 113	engineered mutation
Asn 114	Thr 114	engineered mutation
His 115	Glu 115	engineered mutation
Arg 128	Gln 128	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	8677.6
Non-Polymers*	Number of molecules	1
	Total formula weight	150.2
All*	Total formula weight	8827.7

*Water molecules are not included.