4LC7
Aminooxazoline inhibitor of BACE-1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-Secretase-1 | polymer | 406 | 45445.1 | 1 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 |
2 | A | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
3 | A | (3aR,7aR)-3a-[3-(5-chloropyridin-3-yl)phenyl]-3a,4,5,6,7,7a-hexahydro-1,3-benzoxazol-2-amine | non-polymer | 327.8 | 1 | Chemie (1WP) | |||
4 | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 57 - 453 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Met 56 | - | expression tag |
Arg 454 | - | expression tag |
Ser 455 | - | expression tag |
His 456 | - | expression tag |
His 457 | - | expression tag |
His 458 | - | expression tag |
His 459 | - | expression tag |
His 460 | - | expression tag |
His 461 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45445.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 386.5 | |
All* | Total formula weight | 45831.6 |