4LAC
Crystal Structure of Protein Phosphatase 2A (PP2A) and PP2A phosphatase activator (PTPA) complex with ATPgammaS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Serine/threonine-protein phosphatase 2A activator | polymer | 308 | 35187.5 | 1 | UniProt (Q15257) Pfam (PF03095) In PDB | Homo sapiens (human) | PP2A, subunit B', PR53 isoform, Phosphotyrosyl phosphatase activator, PTPA, Serine/threonine-protein phosphatase 2A regulatory subunit 4, Serine/threonine-protein phosphatase 2A regulatory subunit B' |
| 2 | A | PP2A Scaffold Subunit A, Truncated, an internal deletion of PP2A A | polymer | 258 | 28496.7 | 1 | Pfam (PF02985) UniProt (by SIFTS) (P30153) In PDB | Homo sapiens (human) | |
| 3 | C | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 311 | 35780.3 | 1 | UniProt (P67775) Pfam (PF00149) In PDB | Homo sapiens (human) | PP2A-alpha, Replication protein C, RP-C |
| 4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | C | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | C | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 1 | Chemie (AGS) | |||
| 7 | C | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 8 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
B: 19 - 323 (UniProt: Q15257)
C: 1 - 309 (UniProt: P67775)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Met 18 | - | expression tag |
| - | Ser 71 | deletion |
| - | Glu 72 | deletion |
| - | Met 73 | deletion |
| - | Trp 74 | deletion |
| - | Asn 75 | deletion |
| - | Glu 76 | deletion |
| - | Val 77 | deletion |
| - | His 78 | deletion |
| - | Glu 79 | deletion |
| - | Glu 80 | deletion |
| - | Lys 81 | deletion |
| - | Glu 82 | deletion |
| - | Gln 83 | deletion |
| - | Ala 84 | deletion |
| - | Ala 85 | deletion |
| - | Lys 86 | deletion |
| - | Gln 87 | deletion |
| - | Ser 88 | deletion |
| - | Val 89 | deletion |
| - | Ser 90 | deletion |
| - | Cys 91 | deletion |
| - | Asp 92 | deletion |
| - | Glu 93 | deletion |
| - | Cys 94 | deletion |
| - | Ile 95 | deletion |
| - | Pro 96 | deletion |
| - | Leu 97 | deletion |
| - | Pro 98 | deletion |
| - | Arg 99 | deletion |
| - | Ala 100 | deletion |
| - | Gly 101 | deletion |
| - | His 102 | deletion |
| - | Cys 103 | deletion |
| - | Ala 104 | deletion |
| - | Pro 105 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 99464.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 934.5 | |
| All* | Total formula weight | 100398.9 |
