4L8G
Crystal Structure of K-Ras G12C, GDP-bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase KRas | polymer | 170 | 19374.9 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, KRas-4B |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (A) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | variant |
| Gly 151 | Arg 151 | SEE REMARK 999 |
| Asp 153 | Glu 153 | SEE REMARK 999 |
| Lys 165 | Gln 165 | SEE REMARK 999 |
| His 166 | Tyr 166 | SEE REMARK 999 |
| Lys 167 | Arg 167 | SEE REMARK 999 |
| Glu 168 | Leu 168 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19374.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 490.5 | |
| All* | Total formula weight | 19865.4 |
