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4L7L

Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0368

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APoly [ADP-ribose] polymerase 3polymer35739752.11UniProt (Q9Y6F1)
Pfam (PF02877)
Pfam (PF00644)
In PDB
Homo sapiens (human)PARP-3, hPARP-3, ADP-ribosyltransferase diphtheria toxin-like 3, ARTD3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly[ADP-ribose] synthase 3, pADPRT-3
2AN-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamidenon-polymer351.41Chemie (1VA)
3ADIMETHYL SULFOXIDEnon-polymer78.12Chemie (DMS)
4waterwater18.0127Chemie (HOH)
Sequence modifications
A: 178 - 532 (UniProt: Q9Y6F1)
PDBExternal DatabaseDetails
Ser 176-expression tag
Met 177-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight39752.1
Non-Polymers*Number of molecules3
Total formula weight507.7
All*Total formula weight40259.7
*Water molecules are not included.

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PDB entries from 2024-06-12

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