4L4S

Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (H, A)	L-lactate dehydrogenase A chain	polymer	339	37674.6	2	UniProt (P00338) Pfam (PF00056) Pfam (PF02866)	Homo sapiens (human)	LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59
2	C, D (H, A)	1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE	non-polymer		665.4	2	Chemie (NAI)
3	E, F (H, A)	water	water		18.0	37	Chemie (HOH)

Sequence modifications

H, A: 1 - 331 (UniProt: P00338)

PDB	External Database	Details
Leu 332	-	expression tag
Glu 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75349.2
Non-Polymers*	Number of molecules	2
	Total formula weight	1330.9
All*	Total formula weight	76680.1

*Water molecules are not included.