4L4S
Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (H, A) | L-lactate dehydrogenase A chain | polymer | 339 | 37674.6 | 2 | UniProt (P00338) Pfam (PF00056) Pfam (PF02866) | Homo sapiens (human) | LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59 |
| 2 | C, D (H, A) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 2 | Chemie (NAI) PubChem (928) PubChem (11250888) PubChem (12309341) PubChem (16219774) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (140875346) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (94865921) PubChem (94865923) PubChem (124432988) PubChem (124934831) PubChem (124934833) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875) | |||
| 3 | E, F (H, A) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
H, A: 1 - 331 (UniProt: P00338)
| PDB | External Database | Details |
|---|---|---|
| Leu 332 | - | expression tag |
| Glu 333 | - | expression tag |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75349.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1330.9 | |
| All* | Total formula weight | 76680.1 |
