4L45
Crystal structures of human p70S6K1-T389E
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RPS6KB1 protein | polymer | 346 | 38991.9 | 1 | UniProt (Q7Z721) Pfam (PF00069) Pfam (PF00433) UniProt (by SIFTS) (P23443) | Homo sapiens (human) | Ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase, 70kDa, polypeptide 1, isoform CRA_c |
| 2 | B (A) | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole | non-polymer | 390.4 | 1 | Chemie (5FI) |
Sequence modifications
A: 52 - 394 (UniProt: Q7Z721)
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
| Ala 50 | - | expression tag |
| Met 51 | - | expression tag |
| Glu 389 | Thr 412 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38991.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 390.4 | |
| All* | Total formula weight | 39382.3 |
