4L3P

Crystal Structure of 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine bound to TAK1-TAB1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera	polymer	315	35520.9	1	UniProt (O43318) UniProt (Q15750) Pfam (PF07714) In PDB	Homo sapiens (human)	Tak1-Tab1 fusion protein, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1
2	A	2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine	non-polymer		415.5	1	Chemie (1UH)
3		water	water		18.0	1	Chemie (HOH)

Sequence modifications

A: 31 - 303 (UniProt: O43318)

PDB	External Database	Details
Gly 26	-	expression tag
Ser 27	-	expression tag
Leu 28	-	expression tag
His 29	-	expression tag
Met 30	-	expression tag

A: 468 - 504 (UniProt: Q15750)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35520.9
Non-Polymers*	Number of molecules	1
	Total formula weight	415.5
All*	Total formula weight	35936.4

*Water molecules are not included.