4L3O
Crystal Structure of SIRT2 in complex with the macrocyclic peptide S2iL5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 302 | 34219.5 | 4 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 2, SIR2-like protein 2 |
| 2 | E, F, G, H (E, F, G, H) | cyclic peptide S2iL5 | polymer | 16 | 2044.2 | 4 | BIRD (PRD_001104) | ||
| 3 | I, K, N, R (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | J, L, O, S (A, B, C, D) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 4 | Chemie (MES) | |||
| 5 | M, P, Q, T (B, C, G) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | AA, BA, U, V, W... (G, H, A, B, C...) | water | water | 18.0 | 507 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 145054.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1290.9 | |
| All* | Total formula weight | 146345.7 |
