4L27
Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, D, A, C | Cystathionine beta-synthase | polymer | 548 | 60513.2 | 4 | UniProt (P35520) Pfam (PF00291) Pfam (PF00571) In PDB | Homo sapiens (human) | Beta-thionase, Serine sulfhydrase |
2 | B, D, A, C | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 4 | Chemie (PLP) | |||
3 | B, D, A, C | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) |
Sequence modifications
B, D, A, C: 2 - 551 (UniProt: P35520)
PDB | External Database | Details |
---|---|---|
Asn 444 | Asp 444 | engineered mutation |
- | Ile 516 | deletion |
- | Gln 517 | deletion |
- | Tyr 518 | deletion |
- | His 519 | deletion |
- | Ser 520 | deletion |
- | Thr 521 | deletion |
- | Gly 522 | deletion |
- | Lys 523 | deletion |
- | Ser 524 | deletion |
- | Ser 525 | deletion |
Leu 552 | - | expression tag |
Glu 553 | - | expression tag |
His 554 | - | expression tag |
His 555 | - | expression tag |
His 556 | - | expression tag |
His 557 | - | expression tag |
His 558 | - | expression tag |
His 559 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 242052.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3454.5 | |
All* | Total formula weight | 245507.3 |