4L0P
Structure of the human EphA3 receptor ligand binding domain complexed with ephrin-A5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ephrin type-A receptor 3 | polymer | 176 | 20258.8 | 1 | UniProt (P29320) Pfam (PF01404) | Homo sapiens (human) | EPH-like kinase 4, EK4, hEK4, HEK, Human embryo kinase, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, Eph-like tyrosine kinase 1 |
| 2 | B (B) | Ephrin-A5 | polymer | 143 | 16721.8 | 1 | UniProt (P52803) Pfam (PF00812) | Homo sapiens (human) | AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7 |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, E, G, H, I (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | F (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 29 - 201 (UniProt: P29320)
B: 27 - 166 (UniProt: P52803)
| PDB | External Database | Details |
|---|---|---|
| Gly 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Gly 28 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Gly 26 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36980.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 520.4 | |
| All* | Total formula weight | 37925.4 |
