4KZO
Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 425 | 48135.7 | 3 | UniProt (O75874) Pfam (PF00180) | Homo sapiens (human) | IDH, Cytosolic NADP-isocitrate dehydrogenase, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase |
| 2 | D, H, K (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) PubChem (271) | |||
| 3 | E, I, L (A, B, C) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 3 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 4 | F, J, M (A, B, C) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 3 | Chemie (AKG) PubChem (51) | |||
| 5 | G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | N, O, P (A, B, C) | water | water | 18.0 | 356 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 414 (UniProt: O75874)
| PDB | External Database | Details |
|---|---|---|
| His 132 | Arg 132 | variant |
| Ser 415 | - | expression tag |
| Leu 416 | - | expression tag |
| Glu 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
| His 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 144407.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2850.8 | |
| All* | Total formula weight | 147257.9 |
