4KX8

Crystal structure of human aminopeptidase A complexed with amastatin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glutamyl aminopeptidase	polymer	888	102719.5	1	UniProt (Q07075) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB	Homo sapiens (human)	EAP, Aminopeptidase A, AP-A, Differentiation antigen gp160
2	C	amastatin	polymer	4	474.5	1	BIRD (PRD_000415)	Streptomyces sp. ME98-M3
3	B, F, G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
4	D, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		627.6	2	In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ)		triacetyl-beta-chitotriose
5	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7		water	water		18.0	533	Chemie (HOH)

Sequence modifications

A: 76 - 957 (UniProt: Q07075)

PDB	External Database	Details
Arg 213	Gln 213	variant
Ala 218	Val 218	variant
His 958	-	expression tag
His 959	-	expression tag
His 960	-	expression tag
His 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	103194.0
Branched	Number of molecules	5
	Total formula weight	2528.4
Non-Polymers*	Number of molecules	5
	Total formula weight	950.2
All*	Total formula weight	106672.7

*Water molecules are not included.