4KX8
Crystal structure of human aminopeptidase A complexed with amastatin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamyl aminopeptidase | polymer | 888 | 102719.5 | 1 | UniProt (Q07075) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (human) | EAP, Aminopeptidase A, AP-A, Differentiation antigen gp160 |
| 2 | B (C) | amastatin | polymer | 4 | 474.5 | 1 | BIRD (PRD_000415) | Streptomyces sp. ME98-M3 | |
| 3 | C, F, G (B, F, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, E (D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 2 | In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ) | triacetyl-beta-chitotriose | ||
| 5 | H (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | I, J, K, L (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | M, N (A, C) | water | water | 18.0 | 533 | Chemie (HOH) |
Sequence modifications
A: 76 - 957 (UniProt: Q07075)
| PDB | External Database | Details |
|---|---|---|
| Arg 213 | Gln 213 | variant |
| Ala 218 | Val 218 | variant |
| His 958 | - | expression tag |
| His 959 | - | expression tag |
| His 960 | - | expression tag |
| His 961 | - | expression tag |
| His 962 | - | expression tag |
| His 963 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103194.0 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2528.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 950.2 | |
| All* | Total formula weight | 106672.7 |
